• Finally the potential contribution of CD b cells to

  2018-10-22

  

  Finally, the potential contribution of CD11b+ btk inhibitor to the regenerative microenvironment highlights the experimental challenges in defining the mechanism of lung growth. The distinct transcriptional profiles of the CD11b+ cells, and their migration into different anatomic compartments, sugge

• Subsets of undifferentiated human ES cells have

  2018-10-22

  

  Subsets of undifferentiated human ES cells have been proposed based upon studies of surface antigen markers, such as SSEA3 (Enver et al., 2005) or CD9 and GCTM2 (Laslett et al., 2007). SSEA3 is a cell surface antigen that is rapidly down-regulated as human ES cells differentiate (Draper et al., 2002

• One of the main obstacles in human studies

  2018-10-22

  

  One of the main obstacles in human studies is sample acquisition. Human iPSC lines are usually produced from fibroblasts isolated from skin biopsies, a traumatic invasive procedure demanding local anesthesia and medical follow-up. Hair follicle (HF) plucking, however, is simple, painless and non-inv

• Our results provide evidence that i transcription factor NF

  2018-10-22

  

  Our results provide evidence that (i) transcription factor NF-κB activation is necessary for limbal epithelial outgrowth on intact AM and MMP-9 expression (Fig. 4) and (ii) PI3-K/Akt and JNK pathways are involved in NF-κB activation (Figs. 5 and 6). Our data were supported by recent studies indicati

• In this study we demonstrated that astrocytes

  2018-10-22

  

  In this study, we demonstrated that astrocytes exposed to ACM undergo de-differentiation to multipotent NSPCs which can re-differentiate into neurons, astrocytes, and oligodentrocytes. Whereas blockade of Shh biological functions in ACM does not result in astrocyte de-differentiation to multipotent

• br List of abbreviations and conventions

  2018-10-22

  

  List of abbreviations and conventions for paper AP+ SSEA4+-Stage Specific Embryonic Antigen 4 Disclosure of potential conflicts of interest Acknowledgments The authors thank Miss Heidi Mjoseng for help with tissue culture during the course of this project. This project was supported by co

• We demonstrated that the PI K AKT

  2018-10-22

  

  We demonstrated that the PI3K/AKT signaling pathway plays important roles in regulating hUCBSC differentiation and maintaining the pluripotency of hESCs (Yu et al., 2012). Furthermore, mTOR/p70S6K, a major downstream effector of PI3K/AKT signaling, was found to be phosphorylated, suggesting that HMG

• In the present study we used

  2018-10-22

  

  In the present study, we used a piglet model of cerebral hypoxia–ischemia; a powerful in vivo model which emulates important clinical similarities to human situation of birth asphyxia, to evaluate the NSP cell proliferation, differentiation and neurogenesis in SVZ of newborn piglets subjected to PC

• Identification of miRNA targets is the most important aspect

  2018-10-22

  

  Identification of miRNA targets is the most important aspect in understanding the mechanisms by which miRNAs control cell behavior (Huang et al., 2010; Ivan et al., 2008). Several genes have been identified as miR-210 target genes including Casp8ap2, e2f3, ephrin-A3, neuronal pentraxin 1, MNT, RAD52

• br Conclusions br Author contributions br Conflicts of inter

  2018-10-22

  

  Conclusions Author contributions Conflicts of interest Acknowledgments Introduction Self-renewal is an integrated proliferation control that maintains undifferentiated states of stem cells. The integrated control is achieved by multilayered regulatory networks involving complex interp

• It has been reported that uremic conditions cause

  2018-10-20

  

  It has been reported that uremic conditions cause defects in BMSC self-renewal and differentiation (He et al., 2009; Noh et al., 2012). Our previous studies showed that chronic kidney disease induced by partial nephrectomy (PNx) increases the circulating level of Na/K-ATPase ligands in rat and mouse

• Allogeneic non matched cloned male EGFP transduced porcine e

  2018-10-20

  

  Allogeneic, non-matched, cloned male EGFP-transduced porcine eCSCs, were administered intracoronary in white Yorkshire female pigs, 30min after MI and coronary reperfusion (Ellison et al., 2009). Pig serum was injected to control pigs after MI (CTRL). The SCR7 or sera were injected through a percut

• Introduction Most studies agree that

  2018-10-20

  

  Introduction Most studies agree that the adult heart continues to renew cardiomyocytes even after the neonatal period. Cardiomyocytes can be generated by self-duplication and by cardiac stem 5 alpha reductase (CSCs) (Fig. 1). Both modes of cardiomyocyte renewal have been proposed at different ages

• Induced pluripotent stem cells have emerged

  2018-10-20

  

  Induced pluripotent stem Rapalink-1 have emerged as powerful tool for many applications including disease modelling, drug screening and cell based therapies (Takahashi and Yamanaka, 2016). Therefore, increased efficiency of cell reprogramming is beneficial as it could help reduce the time required

• This work was supported by the

  2018-10-20

  

  This work was supported by the Elsa U. Pardee Foundation research grant, an American Heart Association grant #0765185B, the Wayne State University Cardiovascular Research Institute Isis Initiative award, and American Cancer Society Institutional Research Grant #11-053-01-IRG (to C.L.), and the Leuke

902 records 59/61 page Previous Next First page 上5页 5657585960 下5页 Last page