• br Results br Discussion In previous studies

  2018-10-24

  

  Results Discussion In previous studies, we derived pericytes (Kusuma et al., 2013) and both hiPSC syn-vSMCs and hiPSC con-vSMCs (Wanjare et al., 2013a). In performing direct comparisons between these perivascular cell derivatives, we observed numerous differences that enable the study of human

• Evidence from AD PHP B patients as well as

  2018-10-24

  

  Evidence from AD-PHP1B patients as well as mouse models indicates that the expression levels of the two transcripts, exon A/B and Gsα, are oppositely regulated in cis in imprinted tissues (Plagge and Kelsey 2006; Williamson et al., 2004). Absence of paternal Gsα transcript expression is attributed a

• pkc pathway br Experimental Procedures br Acknowledgments We

  2018-10-24

  

  Experimental Procedures Acknowledgments We thank Ms. Y. Ogata for technical assistance. Financial support for this research was provided by The Uehara Memorial Foundation, and The Ministry of Education, Culture, Sports, Science, and Technology of Japan and the Japan Science and Technology Age

• br Author Contributions br Acknowledgments br Introduction N

  2018-10-24

  

  Author Contributions Acknowledgments Introduction Neurons in the CNS are particularly sensitive to injury and degenerative conditions that frequently result in cell death. Although adult neurogenesis persists in restricted protease inhibitor areas (Gage, 2000; Hsieh, 2012; Kriegstein and A

• 5-aminolevulinic acid Chemotherapy is a standard treatment f

  2018-10-24

  

  Chemotherapy is a standard treatment for patients with advanced disease, including nonresectable, recurrent, or metastatic tumors. Due to chemoresistance, the majority of patients die within three years (Papaspyrou et al., 2011). Indeed, cisplatin and other platinum-based therapies do not present cl

• pten pathway To determine whether overexpression of Sca in p

  2018-10-24

  

  To determine whether overexpression of Sca-1 in progenitor cells residing in the bulge and upper isthmus could function as an initiating event, Rosa:Cre mice and control littermates were treated with TPA only. This treatment resulted in very few papillomas that quickly regressed and there was no sig

• The developments in the field of genetically encoded fluores

  2018-10-24

  

  The developments in the field of genetically encoded fluorescent indicators may provide a possible solution to the aforementioned challenges. Genetically encoded indicators are composed of a sensing element, which is usually fused to an autofluorescent protein (like circularly permuted enhanced GFP;

• br Results br Discussion The

  2018-10-24

  

  Results Discussion The development of miRNA-based therapy approaches has become one of the most attractive areas of tissue engineering (Lian et al., 2012). Recently, many studies reported that miRNAs are important regulators for the therapy or differentiation of stem PI3K Akt mTOR Compound Lib

• br Experimental Procedures br Author Contributions

  2018-10-24

  

  Experimental Procedures Author Contributions Acknowledgments We wish to thank the cytometer unit of CABIMER for technical support, Diana Aguilar for critical reading of the manuscript, and Veronica Raker for style corrections. This work was funded by an R + D + I grant from the Spanish Mini

• In summary our findings identified legumain as a

  2018-10-24

  

  In summary, our findings identified legumain as a “molecular switch” with opposing effects on bone and fat formation by hBMSCs through degradation of the ECM protein fibronectin (Figure 6F) and that altered expression of legumain in the bone microenvironment contributes to the pathophysiology of tra

• br Experimental Procedures br Author Contributions br Acknow

  2018-10-24

  

  Experimental Procedures Author Contributions Acknowledgments We are grateful for the technical assistance of Maria Ensthaler and the support by the “Core facility Cell Sorting.” We also thank the Research Core Unit Transcriptomics of Hannover Medical School for generating and processing the

• br Experimental Procedures br Author Contributions br Acknow

  2018-10-24

  

  Experimental Procedures Author Contributions Acknowledgments We thank A. Villanueva, C. Saura, C. Cruz, A. Fernández, E. Nadal, M. Martin, and R. Iggo for reagents and helpful advice, A. Welm and Y. DeRose for sharing PDX models, V. Peg, X. Serres, J. Balmaña, J. Pérez, and C. Hierro for pr

• Note that essential in orders

  2018-10-24

  

  Note that essential (in 1–2 orders of magnitude) aberration reduction was a result of small complication of the () function. For > is less than that for = 0, and as result, Myriocin dispersion is decreased. For large angles when the dispersion becomes larger, the parameter ≠ in () does not give any

• The experience in systematically calculating flows

  2018-10-24

  

  The experience in systematically calculating flows of this type gained by the authors allows to conclude that numerical solutions obtained for steady laminar flow are highly precise. We should also mention that the low-velocity problem does not arise when analyzing the numerical solutions. With that

• Small conductance calcium activated potassium

  2018-10-24

  

  Small-conductance calcium-activated potassium channels (SK channels) are known to be involved in controlling the pacemaking activity of PCs [8]. Activation of SK channels leads to afterhyperpolarization of the cell membrane, maintaining regular bms-536924 generation and suppressing the PC firing fre

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