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In the present study we used
2018-10-22
In the present study, we used a piglet model of cerebral hypoxia–ischemia; a powerful in vivo model which emulates important clinical similarities to human situation of birth asphyxia, to evaluate the NSP cell proliferation, differentiation and neurogenesis in SVZ of newborn piglets subjected to PC
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Identification of miRNA targets is the most important aspect
2018-10-22
Identification of miRNA targets is the most important aspect in understanding the mechanisms by which miRNAs control cell behavior (Huang et al., 2010; Ivan et al., 2008). Several genes have been identified as miR-210 target genes including Casp8ap2, e2f3, ephrin-A3, neuronal pentraxin 1, MNT, RAD52
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br Conclusions br Author contributions br Conflicts of inter
2018-10-22
Conclusions Author contributions Conflicts of interest Acknowledgments Introduction Self-renewal is an integrated proliferation control that maintains undifferentiated states of stem cells. The integrated control is achieved by multilayered regulatory networks involving complex interp
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It has been reported that uremic conditions cause
2018-10-20
It has been reported that uremic conditions cause defects in BMSC self-renewal and differentiation (He et al., 2009; Noh et al., 2012). Our previous studies showed that chronic kidney disease induced by partial nephrectomy (PNx) increases the circulating level of Na/K-ATPase ligands in rat and mouse
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Allogeneic non matched cloned male EGFP transduced porcine e
2018-10-20
Allogeneic, non-matched, cloned male EGFP-transduced porcine eCSCs, were administered intracoronary in white Yorkshire female pigs, 30min after MI and coronary reperfusion (Ellison et al., 2009). Pig serum was injected to control pigs after MI (CTRL). The SCR7 or sera were injected through a percut
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Introduction Most studies agree that
2018-10-20
Introduction Most studies agree that the adult heart continues to renew cardiomyocytes even after the neonatal period. Cardiomyocytes can be generated by self-duplication and by cardiac stem 5 alpha reductase (CSCs) (Fig. 1). Both modes of cardiomyocyte renewal have been proposed at different ages
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Induced pluripotent stem cells have emerged
2018-10-20
Induced pluripotent stem Rapalink-1 have emerged as powerful tool for many applications including disease modelling, drug screening and cell based therapies (Takahashi and Yamanaka, 2016). Therefore, increased efficiency of cell reprogramming is beneficial as it could help reduce the time required
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This work was supported by the
2018-10-20
This work was supported by the Elsa U. Pardee Foundation research grant, an American Heart Association grant #0765185B, the Wayne State University Cardiovascular Research Institute Isis Initiative award, and American Cancer Society Institutional Research Grant #11-053-01-IRG (to C.L.), and the Leuke
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Although it is possible that reduced shear stresses in
2018-10-20
Although it is possible that reduced shear stresses in the injured colon may have favoured HPC7 adhesion, this study suggests that active adhesive mechanisms, similar to those utilised by inflammatory neutrophils, were actually involved in mediating their recruitment. There has been much recent disc
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The finding that MHC and myogenin expression does not change
2018-10-20
The finding that MHC and myogenin expression does not change upon ectopic Msx1 expression but decreases drastically upon Msx2 expression is another piece of evidence for the selective role of MSX2 in dedifferentiation. The previous two studies on MSX1 induction in myotubes did not characterize MHC l
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br Resource details br Materials and methods br Resource
2018-10-20
Resource details Materials and methods Resource Table Resource details Materials and methods Verification and authentication Resource table: Resource details Materials and methods Resource details. RCM1 was shown to be pluripotent by expression of Oct 4 using immunocytochem
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In the current study we used only gene expression
2018-10-20
In the current study, we used only gene expression data for the analysis; however, phosphoproteomics data could also be used to assign weights to the signaling interactome for the inference of niche determinants. An important limitation of the method is that it considers only DERs as the sources of
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br Experimental Procedures br Acknowledgments
2018-10-20
Experimental Procedures Acknowledgments Introduction The kidney contains multiple specialized cell types that have district physiological functions. During embryogenesis, the urogenital system, including the kidney, is derived from the intermediate mesoderm of the developing embryo (Herzlin
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The results presented here sug http www surface antigen
2018-10-20
The results presented here suggest that HIF and MYC are antagonistic to each other in neurogenesis. While others have suggested that this could be the case in other types of myd88 inhibitor (Koshiji et al., 2004; Yoon et al., 2010), the mechanism proposed here is distinct. We found that a portion of
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Regarding FMR transcription by FXS HESCs we show that FMR
2018-10-20
Regarding FMR1 transcription by FXS HESCs, we show that FMR1 expression in unmethylated FXS HESCs (HEFX, 0% methylation) is indistinguishable from WT HESCs and is significantly reduced in all methylated FXS cell lines. Nevertheless, the relation between the extent of methylation and FMR1 expression