• br Mega cohort studies Remote monitoring collects

  2019-05-28

  

  Mega-cohort studies Remote monitoring collects a wealth of data from large numbers of patients which are not subject to saturation or overwritten memory counters within any implantable device. These databases provide an opportunity to better understand system function, patient condition, and dise

• The exhibited efficacies of bone targeting treatments in pha

  2019-05-28

  

  The exhibited efficacies of bone targeting treatments, in phase III clinical trials, suggest significant progress in delaying skeletal-related events, with improvements having been seen in the direct comparisons between generations of drugs. These findings also lend clear support to the utility of b

• In this section we will

  2019-05-28

  

  In this section we will try and address many of the frequently asked questions around preventive and prophylactic measures for patients either starting or already established on bone-targeted therapy (Figs. 2 and 3). In view of the difficulties in treating ONJ, preventive strategies would seem to ma

• br Patients and methods br Discussion In this

  2019-05-28

  

  Patients and methods Discussion In this GDC0068 secondary endpoint analysis of the OPTION trial, we have shown that the addition of goserelin to neo(adjuvant) chemotherapy temporarily increased bone turnover during treatment and that this reverses over the next 6–12 months after completion of

• Our findings show that primary prevention ICD recipients exp

  2019-05-28

  

  Our findings show that primary prevention ICD recipients experienced an impaired QOL on vitality subscales, which were included in the physical health domain, compared to secondary prevention ICD recipients. Similarly, Berg et al. also found that ICD patients with a primary prevention indication had

• br Conclusions br Conflict of interest br Acknowledgments

  2019-05-27

  

  Conclusions Conflict of interest Acknowledgments This study was based in part on data from the National Health Insurance Research Database provided by the Bureau of National Health Insurance, Department of Health and managed by the National Health Research Institutes (registration number 10

• Bisphosphonates are the cornerstone of

  2019-05-27

  

  Bisphosphonates are the cornerstone of management in postmenopausal osteoporosis with randomised trial evidence of reductions in vertebral fractures for ibandronate [15] and both vertebral and non-vertebral fracture rates for alendronate [16], risedronate [17], and zoledronic the most successful fil

• Bisphosphonates significantly reduce or prevent SREs The use

  2019-05-27

  

  Bisphosphonates significantly reduce or prevent SREs. The use of Zol for patients with bone metastases is currently the gold standard treatment [4]. However, it is still unclear whether Zol contributes to a survival benefit [9]. Niikura et al. recently reported that Zol did not prolong progression-f

• Cerrone et al reported that

  2019-05-27

  

  Cerrone et al. reported that the mechanism of CPVT was due to delayed afterdepolarization‐induced triggered activity in a focal Purkinje network in a knock-in (RyR2) mouse [36]. In addition, chemical ablation of the RV endocardial cavity with Lugol׳s solution, which selectively destroys the Purkinje

• Illicit financial flight is the unrecorded movement of

  2019-05-27

  

  Illicit financial flight is the unrecorded movement of capital out of a country in contravention of the regulations of that country. The main mechanism used to undertake this is multinational companies shifting their tax liabilities to sister companies located in low tax jurisdictions, also known as

• Pregnancies in adolescents year olds and in older women

  2019-05-27

  

  Pregnancies in adolescents (10–19-year-olds) and in older women (≥35 years) are hazardous for the mother and the child. Despite an almost universal decline in the adolescent nitric oxide synthase inhibitors since 1990, adolescent fertility still accounts for 11% of all births worldwide, with 95% of

• En el segundo grupo se ubican los pueblos

  2019-05-27

  

  En el segundo grupo se ubican los pueblos indígenas y comunidades afectadas por la industria extractiva, los mismos que han protagonizado intensas y masivas protestas en puntos tan disímiles del territorio nacional como Cajamarca, Arequipa, Piura o la Amazonía. Se trata de diversas poblaciones que o

• La mayor parte de las actividades del movimiento durante los

  2019-05-27

  

  La mayor parte de las actividades del movimiento durante los meses siguientes se dedicó alkaline phosphatase inhibitors la recaudación de fondos con destino a financiar las actividades de insurrección en el interior de España. En este sentido, se orientaron actividades tales como la creación de un g

• Assim a decis o de avan ar

  2019-05-27

  

  Assim, AMG 925 decisão de avançar sobre Lima deve ser entendida antes como uma “fuga para frente” do que como desdobramento de um crescimento orgânico. Mas em seu momento, havia um genuíno receio em relação ao poder insurgente, já que a repercussão das ações senderistas na capital era amplificada.

• br The Millennium Development Goals on health

  2019-05-27

  

  The Millennium Development Goals on health have expanded access to basic health interventions to millions of people in low-income and middle-income countries (LMICs). However, access alone will not be sufficient to meet the Sustainable Development Goals (SDGs) if health systems cannot provide high

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